When Shouldn'T You Take Alli?

Don't take Alli if you:

* Are at a healthy weight
* Are taking cyclosporine
* Have had an organ transplant
* Have problems absorbing food

The drug also may pose risks for anyone who takes blood-thinning medication or has diabetes or thyroid disease.

Orlistat decreases the absorption of certain fat-soluble vitamins — for example, vitamins A, D and E. If you're taking Alli, you need to take a daily vitamin supplement (at a time different from when you take Alli) to prevent potential nutrient deficiencies.